4-Amino-1-methylpiperidine → HCID 59208064, compound

HRID 2243753Notes

Reaction equation

HRID 2243753 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[N:9]1[C:14]2[N:15]=[C:16](S(C)(=O)=O)[N:17]=[C:18]([C:19]3[CH:20]=[C:21]([CH:29]=[CH:30][C:31]=3[CH3:32])[C:22]([N:24]([CH2:27][CH3:28])[CH2:25][CH3:26])=[O:23])[C:13]=2[CH2:12][NH:11][C:10]1=[O:37].[CH3:38][N:39]1[CH2:44][CH2:43][CH:42]([NH2:45])[CH2:41][CH2:40]1>C1COCC1>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[N:9]1[C:14]2[N:15]=[C:16]([NH:45][CH:42]3[CH2:43][CH2:44][N:39]([CH3:38])[CH2:40][CH2:41]3)[N:17]=[C:18]([C:19]3[CH:20]=[C:21]([CH:29]=[CH:30][C:31]=3[CH3:32])[C:22]([N:24]([CH2:27][CH3:28])[CH2:25][CH3:26])=[O:23])[C:13]=2[CH2:12][NH:11][C:10]1=[O:37]

Participants

4

Reactant 2

HCID 27375314-Amino-1-methylpiperidineHCID 59208006HCID 59208006, compound

Product 1

HCID 59208064HCID 59208064, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3-[8-(2,6-difluorophenyl)-2-(methylsulfonyl)-7-oxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-yl]-N,N-diethyl-4-methylbenzamide-(0.053 g, 0.1 mmol) was dissolved in THF (5 mL) and 1-methyl-4-piperidinamine (0.044 g, 0.5 mmol) was added. The reaction was stirred under argon overnight. The solvents were pumped off in vacuo, and the residue was purified by mass directed auto prep. The fractions were evaporated, and aqueous basic workup gave the title compound as a white amorphous solid. mp 165-169° C. LC-MS m/z 564 (M+H)+, 1.44 min (ret time).

Workup

  1. customthe residue was purified by mass
  2. customThe fractions were evaporated

Sources & evidence

ORD record
ord-fb5c5d9804cb4015af93146b2baa5ca4
Source dataset
uspto-grants-2010_03
Patent number
US07674789B2

Reaction notes

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