3-Bromo-1-propanol → HCID 68514762, compound

HRID 2243775Notes

Reaction equation

HRID 2243775 reaction equation
[CH3:1][N:2]1[C:7]([CH3:8])=[CH:6][C:5]([CH3:9])=[N:4][C:3]1=[O:10].[Br:11][CH2:12][CH2:13][CH2:14][OH:15]>C(#N)C>[Br-:11].[OH:15][CH2:14][CH2:13][CH2:12][NH+:4]1[C:5]([CH3:9])=[CH:6][CH:7]([CH3:8])[N:2]([CH3:1])[C:3]1=[O:10]

Participants

4

Reactant 2

HCID 123083-Bromo-1-propanolHCID 853977HCID 853977, compound

Product 1

HCID 68514762HCID 68514762, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 10.0 g (0.072 mol) of 1,4,6-trimethylpyrimidin-2(1H)-one and 20.6 g (0.144 mol) of 3-bromopropanol was heated under reflux in acetonitrile for 16 hours under an inert gas atmosphere. After cooling, a pale pink-colored solid precipitated out, which was filtered off with suction (starting material). The filtrate was admixed with chloroform, then the same amount of diethyl ether was added. The product separated out in the form of an oil.

Workup

  1. temperaturewas heated
  2. temperatureAfter cooling
  3. customa pale pink-colored solid precipitated out
  4. filtrationwhich was filtered off with suction (starting material)
  5. additionthe same amount of diethyl ether was added
  6. customThe product separated out in the form of an oil

Sources & evidence

ORD record
ord-5465123996a34468b782c76b0beb8827
Source dataset
uspto-grants-2010_03
Patent number
US07678156B2

Reaction notes

Loading…