Dichloromethane → HCID 86606176, compound

HRID 2243823Notes

Reaction equation

HRID 2243823 reaction equation
C(N=C=S)C.[N:6]12[CH2:14][CH2:13][CH:10]([CH2:11][CH2:12]1)[N:9]([C:15]([C:17]1[O:18][C:19]([C:22]3[CH:27]=[CH:26][C:25]([NH2:28])=[CH:24][CH:23]=3)=[CH:20][CH:21]=1)=[O:16])[CH2:8][CH2:7]2.[Cl:29][CH2:30]Cl>>[Cl-:29].[Cl:29][CH2+:30].[N:6]12[CH2:12][CH2:11][CH:10]([CH2:13][CH2:14]1)[N:9]([C:15]([C:17]1[O:18][C:19]([C:22]3[CH:27]=[CH:26][C:25]([NH2:28])=[CH:24][CH:23]=3)=[CH:20][CH:21]=1)=[O:16])[CH2:8][CH2:7]2

Participants

4

Reactant 3

HCID 6344Dichloromethane2×HCID 10966Ethyl isothiocyanateHCID 10425586HCID 10425586, compound

Product 1

HCID 86606176HCID 86606176, compound

Conditions

Temperature
5 °C

Procedure

Ethylisothiocyanate (182 mg; 2.09 mmol) solved in dichloromethane (20 ml) was added dropwise to a mixture of (1,4-diaza-bicyclo[3.2.2]non-4-yl)-5-(4-aminophenyl)-furan-2-yl-methanone and dichloromethane (10 ml) at 5° C. The mixture was allowed to stir for 4 hours at 5° C. and 11 hours at room temperature. The solvent volume was reduced to a third and the solid product was isolated by filtration. Mp. >300° C.

Workup

  1. customthe solid product was isolated by filtration

Sources & evidence

ORD record
ord-85c42c7943894d42b3a56fb0d0354c54
Source dataset
uspto-grants-2010_03
Patent number
US07678788B2

Reaction notes

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