反应详情

The title compound of Example 11 (8.34 g, 42.5 mmol), sodium azide (3.04 g, 46.8 mmol), and ammonium chloride (2.50 g, 46.8 mmol) were stirred in DMF (30 mL) at 100° C. for 12 h. The reaction was concentrate and partitioned with DCM and 3 M HCl. The organic extracts were dried over sodium sulphate, filtered and concentrated. The resulting solid was triturated with ether and filtered to afford the title product (5.31 g, 52%) as a white solid.

1. concentrationThe reaction was concentrate
2. custompartitioned with DCM and 3 M HCl
3. dry with materialThe organic extracts were dried over sodium sulphate
4. filtrationfiltered
5. concentrationconcentrated
6. customThe resulting solid was triturated with ether
7. filtrationfiltered