Hydrazine hydrate (1:1) → Pyrazine-2-Carboxylic Acid Hydrazide

Participants

Reaction Conditions

Reaction Steps

To the title compound of Example 19.1 (1.28 mg, 9.3 mmol) in ethanol (10 mL) was added hydrazine hydrate (0.54 mL, 11.1 mmol) and then heated at 78° C. overnight. The reaction mixture was cooled and concentrated in vacuo. The residue was triturated with ethyl acetate, filtered and dried to give the title product as a yellow solid (870 mg, 68%).

Provenance & Evidence