Hydrazine hydrate (1:1) → Pyrazine-2-Carboxylic Acid Hydrazide

HRID 2243887Notes

Reaction equation

HRID 2243887 reaction equation
C[O:2][C:3]([C:5]1[CH:10]=[N:9][CH:8]=[CH:7][N:6]=1)=O.O.[NH2:12][NH2:13]>C(O)C>[N:6]1[CH:7]=[CH:8][N:9]=[CH:10][C:5]=1[C:3]([NH:12][NH2:13])=[O:2]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 72662Methyl pyrazinoate

Product 1

HCID 258796Pyrazine-2-Carboxylic Acid HydrazideYield 68%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
78 °C

Procedure

To the title compound of Example 19.1 (1.28 mg, 9.3 mmol) in ethanol (10 mL) was added hydrazine hydrate (0.54 mL, 11.1 mmol) and then heated at 78° C. overnight. The reaction mixture was cooled and concentrated in vacuo. The residue was triturated with ethyl acetate, filtered and dried to give the title product as a yellow solid (870 mg, 68%).

Workup

  1. temperatureThe reaction mixture was cooled
  2. concentrationconcentrated in vacuo
  3. customThe residue was triturated with ethyl acetate
  4. filtrationfiltered
  5. customdried

Sources & evidence

ORD record
ord-9f145b3766064ff4824e88194c96ae08
Source dataset
uspto-grants-2010_03
Patent number
US07678796B2

Reaction notes

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