Hydrazine hydrate (1:1) → 1-Methyl-6-oxo-1,6-dihydropyridine-3-carbohydrazide

Participants

Reaction Conditions

Reaction Steps

The title compound of Example 27 (775 mg, 4.64 mmol) was dissolved in ethanol (10 mL) and heated to 78° C. Hydrazine hydrate (1.12 mL, 23.2 mmol) was added and the reaction was stirred at 78° C. overnight. The reaction was then cooled to room temperature and the product (white solid) was filtered off (590 mg, 76%).

Provenance & Evidence