Hydrazine hydrate (1:1) → 1-Methyl-6-oxo-1,6-dihydropyridine-3-carbohydrazide
Reaction equation
C[O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8](=[O:11])[N:7]([CH3:12])[CH:6]=1)=O.O.[NH2:14][NH2:15]>C(O)C>[CH3:12][N:7]1[C:8](=[O:11])[CH:9]=[CH:10][C:5]([C:3]([NH:14][NH2:15])=[O:2])=[CH:6]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 78 °C
Procedure
The title compound of Example 27 (775 mg, 4.64 mmol) was dissolved in ethanol (10 mL) and heated to 78° C. Hydrazine hydrate (1.12 mL, 23.2 mmol) was added and the reaction was stirred at 78° C. overnight. The reaction was then cooled to room temperature and the product (white solid) was filtered off (590 mg, 76%).
Workup
- temperatureThe reaction was then cooled to room temperature
- filtrationthe product (white solid) was filtered off (590 mg, 76%)
Sources & evidence
- ORD record
- ord-5da0e60bb0954689b3a8b87e58da7014
- Source dataset
- uspto-grants-2010_03
- Patent number
- US07678796B2
Reaction notes
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