Hydrazine hydrate (1:1) → (1SR,8RS)-5-(3-Fluoro-2-trifluoromethyl-phenyl)-3,4-diaza-tricyclo[6.2.1.02,7]undeca-2,4,6-triene

HRID 2243907Notes

Reaction equation

HRID 2243907 reaction equation
[CH:1]12[CH2:7][CH:4]([CH2:5][CH2:6]1)[C:3](=O)[C:2]2=O.COP([CH2:16][C:17]([C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[C:20]=1[C:26]([F:29])([F:28])[F:27])=O)(=O)OC.O.[NH2:31][NH2:32]>>[F:25][C:21]1[C:20]([C:26]([F:29])([F:28])[F:27])=[C:19]([C:17]2[CH:16]=[C:3]3[C:2]([CH:1]4[CH2:7][CH:4]3[CH2:5][CH2:6]4)=[N:32][N:31]=2)[CH:24]=[CH:23][CH:22]=1

Participants

4

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 138696Bicyclo(2.2.1)heptane-2,3-dioneHCID 86609913[2-(3-Fluoro-2-trifluoromethyl-phenyl)-2-oxo-ethyl]-phosphonic acid dimethyl ester

Product 1

HCID 16063585(1SR,8RS)-5-(3-Fluoro-2-trifluoromethyl-phenyl)-3,4-diaza-tricyclo[6.2.1.02,7]undeca-2,4,6-triene

Procedure

light-yellow gum. MS (EI): 308.1 (M+). Prepared from bicyclo[2.2.1]heptane-2,3-dione, [2-(3-Fluoro-2-trifluoromethyl-phenyl)-2-oxo-ethyl]-phosphonic acid dimethyl ester, hydrazine monohydrate.

Sources & evidence

ORD record
ord-9b4df31242c844d6a0d0bfe4f1fefdd7
Source dataset
uspto-grants-2010_03
Patent number
US07678795B2

Reaction notes

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