Hydrazine hydrate (1:1) → 3-(3-Fluoro-2-trifluoromethyl-phenyl)-5,6,7,8,9,10-hexahydro-cycloocta[c]pyridazine

HRID 2243912노트

반응식

HRID 2243912 반응식
[C:1]1(=O)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][C:2]1=O.COP([CH2:17][C:18]([C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[C:21]=1[C:27]([F:30])([F:29])[F:28])=O)(=O)OC.O.[NH2:32][NH2:33]>>[F:26][C:22]1[C:21]([C:27]([F:30])([F:29])[F:28])=[C:20]([C:18]2[N:33]=[N:32][C:2]3[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:1]=3[CH:17]=2)[CH:25]=[CH:24][CH:23]=1

참가 물질

4

반응물 3

HCID 24654Hydrazine hydrate (1:1)HCID 5436981,2-CyclooctanedioneHCID 86609913[2-(3-Fluoro-2-trifluoromethyl-phenyl)-2-oxo-ethyl]-phosphonic acid dimethyl ester

생성물 1

HCID 160636273-(3-Fluoro-2-trifluoromethyl-phenyl)-5,6,7,8,9,10-hexahydro-cycloocta[c]pyridazine

실험 절차

MS (EI): 324.2 (M+), light-yellow solid. Prepared from cyclooctane-1,2-dione, [2-(3-Fluoro-2-trifluoromethyl-phenyl)-2-oxo-ethyl]-phosphonic acid dimethyl ester, hydrazine monohydrate.

출처 및 근거

ORD 기록
ord-10c702b105b149909667c511540f7e63
출처 데이터셋
uspto-grants-2010_03
특허 번호
US07678795B2

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