Hydrazine hydrate (1:1) → 3-(5-Fluoro-2-trifluoromethyl-phenyl)-5,6,7,8,9,10-hexahydro-cycloocta[c]pyridazine

HRID 2243913Notes

Reaction equation

HRID 2243913 reaction equation
[C:1]1(=O)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][C:2]1=O.COP([CH2:17][C:18]([C:20]1[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:21]=1[C:27]([F:30])([F:29])[F:28])=O)(=O)OC.O.[NH2:32][NH2:33]>>[F:26][C:24]1[CH:23]=[CH:22][C:21]([C:27]([F:30])([F:29])[F:28])=[C:20]([C:18]2[N:33]=[N:32][C:2]3[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:1]=3[CH:17]=2)[CH:25]=1

Participants

4

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 5436981,2-CyclooctanedioneHCID 86609914[2-(5-Fluoro-2-trifluoromethyl-phenyl)-2-oxo-ethyl]-phosphonic acid dimethyl ester

Product 1

HCID 670149543-(5-Fluoro-2-trifluoromethyl-phenyl)-5,6,7,8,9,10-hexahydro-cycloocta[c]pyridazine

Procedure

yellow oil. MS (EI): 324.2 (M+). Prepared from cyclooctane-1,2-dione, [2-(5-Fluoro-2-trifluoromethyl-phenyl)-2-oxo-ethyl]-phosphonic acid dimethyl ester, hydrazine monohydrate.

Sources & evidence

ORD record
ord-b51d544d607340738419208d89fad1e8
Source dataset
uspto-grants-2010_03
Patent number
US07678795B2

Reaction notes

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