Hydrazine hydrate (1:1) → HCID 67364540, compound

HRID 2243915Notes

Reaction equation

[CH3:1][C@@:2]12[C:8]([CH3:10])([CH3:9])[C@@H:5]([CH2:6][CH2:7]1)[C:4](=O)[C:3]2=O.COP([CH2:19][C:20]([C:22]1[CH:27]=[C:26]([F:28])[C:25]([F:29])=[CH:24][C:23]=1[Cl:30])=O)(=O)OC.O.[NH2:32][NH2:33]>>[Cl:30][C:23]1[CH:24]=[C:25]([F:29])[C:26]([F:28])=[CH:27][C:22]=1[C:20]1[CH:19]=[C:4]2[C:3]([C@:2]3([CH3:1])[C:8]([CH3:10])([CH3:9])[C@H:5]2[CH2:6][CH2:7]3)=[N:33][N:32]=1

Participants

Reactant 3

HCID 24654Hydrazine hydrate (1:1)

HCID 1549179(+)-Camphorquinone

HCID 86609918HCID 86609918, compound

Product 1

HCID 67364540HCID 67364540, compound

Procedure

yellow oil. MS (EI): 334.1 (M+). Prepared from (1S,4R)-1,7,7-trimethyl-bicyclo[2.2.1]heptane-2,3-dione, [2-(2-Chloro-4,5-difluoro-phenyl)-2-oxo-ethyl]-phosphonic acid dimethyl ester, hydrazine monohydrate.

Sources & evidence

ORD record: ord-ee99b3030a404902bbcf98c600f1105a
Source dataset: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07678795B2

Reaction notes

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