Hydrazine hydrate (1:1) → 3-Cyclopropyl-5,6,7,8,9,10-hexahydrocycloocta[c]pyridazine

HRID 2243916Notes

Reaction equation

HRID 2243916 reaction equation
[C:1]1(=O)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][C:2]1=O.COP([CH2:17][C:18]([CH:20]1[CH2:22][CH2:21]1)=O)(=O)OC.O.[NH2:24][NH2:25]>>[CH:20]1([C:18]2[N:25]=[N:24][C:2]3[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:1]=3[CH:17]=2)[CH2:22][CH2:21]1

Participants

4

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 5436981,2-CyclooctanedioneHCID 57624838Dimethyl (2-cyclopropyl-2-oxoethyl)phosphonate

Product 1

HCID 160636313-Cyclopropyl-5,6,7,8,9,10-hexahydrocycloocta[c]pyridazine

Procedure

yellow oil. MS (ESI): 292.9 (MH+). Prepared from cyclooctane-1,2-dione, (2-cyclopropyl-2-oxo-ethyl)-phosphonic acid dimethyl ester, hydrazine monohydrate.

Sources & evidence

ORD record
ord-60b7da45bb8542c18f23f99f6d3ba89e
Source dataset
uspto-grants-2010_03
Patent number
US07678795B2

Reaction notes

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