Hydrazine hydrate (1:1) → 3-(1-Phenyl-5-trifluoromethyl-1H-pyrazol-4-yl)-5,6,7,8,9,10-hexahydro-cycloocta[c]pyridazine

HRID 2243921Notes

Reaction equation

HRID 2243921 reaction equation
[C:1]1(=O)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][C:2]1=O.COP([CH2:17][C:18](=O)[C:19]1[CH:20]=[N:21][N:22]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:23]=1[C:24]([F:27])([F:26])[F:25])(=O)OC.O.[NH2:36][NH2:37]>>[C:28]1([N:22]2[C:23]([C:24]([F:27])([F:26])[F:25])=[C:19]([C:18]3[N:37]=[N:36][C:2]4[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:1]=4[CH:17]=3)[CH:20]=[N:21]2)[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1

Participants

4

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 5436981,2-CyclooctanedioneHCID 86609920[2-oxo-2-(1-phenyl-5-trifluoromethyl-1H-pyrazol-4-yl)-ethyl]-phosphonic acid dimethyl ester

Product 1

HCID 160636663-(1-Phenyl-5-trifluoromethyl-1H-pyrazol-4-yl)-5,6,7,8,9,10-hexahydro-cycloocta[c]pyridazine

Procedure

light yellow solid. MS (EI): 372.3 (M+). Prepared from cyclooctane-1,2-dione, [2-oxo-2-(1-phenyl-5-trifluoromethyl-1H-pyrazol-4-yl)-ethyl]-phosphonic acid dimethyl ester, hydrazine monohydrate.

Sources & evidence

ORD record
ord-58591d322f9f49e7ab8c197dd5ff7b83
Source dataset
uspto-grants-2010_03
Patent number
US07678795B2

Reaction notes

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