Hydrazine hydrate (1:1) → (1S,8R)-5-(2-Methoxy-phenyl)-1,11,11-trimethyl-3,4-diaza-tricyclo[6.2.1.02,7]undeca-2,4,6-triene

反応式

[CH3:1][C@@:2]12[C:8]([CH3:10])([CH3:9])[C@@H:5]([CH2:6][CH2:7]1)[C:4](=O)[C:3]2=O.COP([CH2:19][C:20]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[O:28][CH3:29])=O)(=O)OC.O.[NH2:31][NH2:32]>>[CH3:29][O:28][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=1[C:20]1[CH:19]=[C:4]2[C:3]([C@:2]3([CH3:1])[C:8]([CH3:10])([CH3:9])[C@H:5]2[CH2:6][CH2:7]3)=[N:32][N:31]=1

参加物

反応物 3

HCID 24654Hydrazine hydrate (1:1)

HCID 1549179(+)-Camphorquinone

HCID 86252899[2-(2-Methoxy-phenyl)-2-oxo-ethyl]-phosphonic acid dimethyl ester

生成物 1

HCID 67364633(1S,8R)-5-(2-Methoxy-phenyl)-1,11,11-trimethyl-3,4-diaza-tricyclo[6.2.1.02,7]undeca-2,4,6-triene

実験手順

yellow solid. MS (EI): 294.3 (M+). Prepared from (1S,4R)-1,7,7-trimethyl-bicyclo[2.2.1]heptane-2,3-dione, [2-(2-Methoxy-phenyl)-2-oxo-ethyl]-phosphonic acid dimethyl ester, hydrazine monohydrate

出典と根拠

ORDレコード: ord-170edaa9668f4f2f9879d10a421b54c9
出典データセット: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07678795B2

反応ノート

読み込み中…