Hydrazine hydrate (1:1) → (1S,8R)-5-(4-Chloro-2-methyl-phenyl)-3,4-diaza-tricyclo[6.2.1.02,7]undeca-2(7),3,5-triene

HRID 2243933Notes

Reaction equation

HRID 2243933 reaction equation
[CH:1]12[CH2:7][CH:4]([CH2:5][CH2:6]1)[C:3](=O)[C:2]2=O.COP([CH2:16][C:17]([C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][C:20]=1[CH3:26])=O)(=O)OC.O.[NH2:28][NH2:29]>>[Cl:25][C:22]1[CH:23]=[CH:24][C:19]([C:17]2[N:28]=[N:29][C:2]3[C@@H:1]4[CH2:7][C@H:4]([C:3]=3[CH:16]=2)[CH2:5][CH2:6]4)=[C:20]([CH3:26])[CH:21]=1

Participants

4

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 138696Bicyclo(2.2.1)heptane-2,3-dioneHCID 86609922[2-(4-Chloro-2-methyl-phenyl)-2-oxo-ethyl]-phosphonic acid dimethyl ester

Product 1

HCID 67364723(1S,8R)-5-(4-Chloro-2-methyl-phenyl)-3,4-diaza-tricyclo[6.2.1.02,7]undeca-2(7),3,5-triene

Procedure

MS (EI): 270.2 (M+), yellow waxy solid. Prepared from bicyclo[2.2.1]heptane-2,3-dione, [2-(4-Chloro-2-methyl-phenyl)-2-oxo-ethyl]-phosphonic acid dimethyl ester, hydrazine monohydrate.

Sources & evidence

ORD record
ord-11d9098269f6481aa331f78b93c33f52
Source dataset
uspto-grants-2010_03
Patent number
US07678795B2

Reaction notes

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