Hydrazine hydrate (1:1) → 3-(2,4-Difluoro-phenyl)-6,6-dimethyl-6,7-dihydro-5H-cyclopenta[c]pyridazine

HRID 2243946Notes

Reaction equation

HRID 2243946 reaction equation
[CH3:1][C:2]1([CH3:9])[CH2:6][C:5](=O)[C:4](=O)[CH2:3]1.COP([CH2:16][C:17]([C:19]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:20]=1[F:26])=O)(=O)OC.O.[NH2:28][NH2:29]>>[F:26][C:20]1[CH:21]=[C:22]([F:25])[CH:23]=[CH:24][C:19]=1[C:17]1[N:29]=[N:28][C:4]2[CH2:3][C:2]([CH3:9])([CH3:1])[CH2:6][C:5]=2[CH:16]=1

Participants

4

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 142896544,4-Dimethylcyclopentane-1,2-dioneHCID 86252856[2-(2,4-Difluoro-phenyl)-2-oxo-ethyl]-phosphonic acid dimethyl ester

Product 1

HCID 160637433-(2,4-Difluoro-phenyl)-6,6-dimethyl-6,7-dihydro-5H-cyclopenta[c]pyridazine

Procedure

yellow solid. MS (EI): 260.1 (M+). Prepared from 4,4-dimethyl-cyclopentane-1,2-dione, [[2-(2,4-difluoro-phenyl)-2-oxo-ethyl]-phosphonic acid dimethyl ester, hydrazine monohydrate.

Sources & evidence

ORD record
ord-cee72430c7f846e4b1f33b14ebb64860
Source dataset
uspto-grants-2010_03
Patent number
US07678795B2

Reaction notes

Loading…