Hydrazine hydrate (1:1) → (1S,8R)-5-(1-tert-Butyl-5-trifluoromethyl-1H-pyrazol-4-yl)-1,11,11-trimethyl-3,4-diaza-tricyclo[6.2.1.02,7]undeca-2,4,6-triene

HRID 2243948Notes

Reaction equation

HRID 2243948 reaction equation
[CH3:1][C:2]12[C:8]([CH3:10])([CH3:9])[CH:5]([CH2:6][CH2:7]1)[C:4](=O)[C:3]2=O.COP([CH2:19][C:20]([C:22]1[CH:23]=[N:24][N:25]([C:31]([CH3:34])([CH3:33])[CH3:32])[C:26]=1[C:27]([F:30])([F:29])[F:28])=O)(=O)OC.O.[NH2:36][NH2:37]>>[C:31]([N:25]1[C:26]([C:27]([F:30])([F:29])[F:28])=[C:22]([C:20]2[CH:19]=[C:4]3[C:3]([C@:2]4([CH3:1])[C:8]([CH3:10])([CH3:9])[C@H:5]3[CH2:6][CH2:7]4)=[N:37][N:36]=2)[CH:23]=[N:24]1)([CH3:34])([CH3:33])[CH3:32]

Participants

4

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 25208Bornane-2,3-dioneHCID 86609927[2-(1-tert-Butyl-5-trifluoromethyl-1H-pyrazol-4-yl)-2-oxo-ethyl]-phosphonic acid dimethyl ester

Product 1

HCID 67364377(1S,8R)-5-(1-tert-Butyl-5-trifluoromethyl-1H-pyrazol-4-yl)-1,11,11-trimethyl-3,4-diaza-tricyclo[6.2.1.02,7]undeca-2,4,6-triene

Procedure

yellow solid. MS (ESI): 379.2 (MH+). Prepared from 1,7,7-trimethyl-bicyclo[2.2.1]heptane-2,3-dione, [2-(1-tert-Butyl-5-trifluoromethyl-1H-pyrazol-4-yl)-2-oxo-ethyl]-phosphonic acid dimethyl ester, hydrazine monohydrate.

Sources & evidence

ORD record
ord-df41b2b82b3e4d7d9c901b26e091c4cc
Source dataset
uspto-grants-2010_03
Patent number
US07678795B2

Reaction notes

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