Hydrazine hydrate (1:1) → 6,6-Dimethyl-3-(2-trifluoromethoxy-phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridazine

HRID 2243954Notes

Reaction equation

HRID 2243954 reaction equation
[CH3:1][C:2]1([CH3:9])[CH2:6][C:5](=O)[C:4](=O)[CH2:3]1.COP([CH2:16][C:17](=O)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[O:24][C:25]([F:28])([F:27])[F:26])(=O)OC.O.[NH2:31][NH2:32]>>[CH3:1][C:2]1([CH3:9])[CH2:6][C:5]2[N:31]=[N:32][C:17]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[O:24][C:25]([F:28])([F:27])[F:26])=[CH:16][C:4]=2[CH2:3]1

Participants

4

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 142896544,4-Dimethylcyclopentane-1,2-dioneHCID 86609928[2-Oxo-2-(2-trifluoromethoxy-phenyl)-ethyl]-phosphonic acid dimethyl ester

Product 1

HCID 160637446,6-Dimethyl-3-(2-trifluoromethoxy-phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridazine

Procedure

light yellow oil. MS (ESI): 309.0 (MH+). Prepared from 4,4-dimethyl-cyclopentane-1,2-dione, [2-Oxo-2-(2-trifluoromethoxy-phenyl)-ethyl]-phosphonic acid dimethyl ester, hydrazine monohydrate.

Sources & evidence

ORD record
ord-275abb8fdb5b4b3a84f216ef2048721b
Source dataset
uspto-grants-2010_03
Patent number
US07678795B2

Reaction notes

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