Hydrazine hydrate (1:1) → 3-(3-Fluoro-2-trifluoromethyl-phenyl)-6,6-dimethyl-6,7-dihydro-5H-cyclopenta[c]pyridazine

HRID 2243977Notes

Reaction equation

HRID 2243977 reaction equation
[CH3:1][C:2]1([CH3:9])[CH2:6][C:5](=O)[C:4](=O)[CH2:3]1.COP([CH2:16][C:17]([C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[C:20]=1[C:26]([F:29])([F:28])[F:27])=O)(=O)OC.O.[NH2:31][NH2:32]>>[F:25][C:21]1[C:20]([C:26]([F:29])([F:28])[F:27])=[C:19]([C:17]2[N:32]=[N:31][C:4]3[CH2:3][C:2]([CH3:9])([CH3:1])[CH2:6][C:5]=3[CH:16]=2)[CH:24]=[CH:23][CH:22]=1

Participants

4

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 142896544,4-Dimethylcyclopentane-1,2-dioneHCID 86609913[2-(3-Fluoro-2-trifluoromethyl-phenyl)-2-oxo-ethyl]-phosphonic acid dimethyl ester

Product 1

HCID 160637753-(3-Fluoro-2-trifluoromethyl-phenyl)-6,6-dimethyl-6,7-dihydro-5H-cyclopenta[c]pyridazine

Procedure

light yellow solid. MS (EI): 310.2 (M+). Prepared from 4,4-dimethyl-cyclopentane-1,2-dione, [2-(3-Fluoro-2-trifluoromethyl-phenyl)-2-oxo-ethyl]-phosphonic acid dimethyl ester, hydrazine monohydrate.

Sources & evidence

ORD record
ord-e7f85a25127149cfa3fceb68298f7ff0
Source dataset
uspto-grants-2010_03
Patent number
US07678795B2

Reaction notes

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