Hydrazine → 7-Hydrazino-quinazolin-4-ylamine

HRID 2244062Notes

Reaction equation

HRID 2244062 reaction equation
F[C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH2:12])=[N:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[NH2:13][NH2:14]>C(O)(C)C>[NH:13]([C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH2:12])=[N:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1)[NH2:14]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 468357077-Fluoroquinazolin-4-amine

Product 1

HCID 250594367-Hydrazino-quinazolin-4-ylamine

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

7-Fluoro-quinazolin-4-ylamine (0.306 mmol, 50 mg) is dissolved in Hydrazine (2 mL) and heated in an open flask until all the liquid is gone. The resulting solid is taken up in isopropanol and stirred for 30 minutes and the solid is collected by filtration. This gives desired product 7-Hydrazino-quinazolin-4-ylamine (32 mg, LC/MS m/z=176 [M+H]+) as a tan powder.

Workup

  1. temperatureheated in an open flask until all the liquid
  2. filtrationthe solid is collected by filtration

Sources & evidence

ORD record
ord-1ee8694027d94c3fa290aa4bc49d3a90
Source dataset
uspto-grants-2010_03
Patent number
US07678803B2

Reaction notes

Loading…