反应详情

To a solution of 6-fluoroisoquinoline (2.64 g, 17.9 mmol) in CH2Cl2 (70 mL) cooled at 0° C., MCPBA is added (3.4 g, 19.69 mmol). The reaction mixture is stirred at RT for 16 h. After 1 h of stirring, a yellow white precipitate forms. The solvent is evaporated under reduced pressure. To the yellow solid is added CH2Cl2 (5 mL), and the solid is isolated by vacuum filtration. Rinsing the solid with CH2Cl2 yields a white solid, which is dried under vacuum to afford 3 g (100%) of 6-fluoro-isoquinoline N-oxide.

1. stirringAfter 1 h of stirring
2. customThe solvent is evaporated under reduced pressure
3. additionTo the yellow solid is added CH2Cl2 (5 mL)
4. customthe solid is isolated by vacuum filtration
5. washRinsing the solid with CH2Cl2
6. customyields a white solid, which
7. customis dried under vacuum