Isoquinoline → 1341688-75-2

HRID 2244123Notes

Reaction equation

HRID 2244123 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1.O[CH2:12][NH:13]C(=O)C(F)(F)F>>[CH:1]1[C:10]2[C:5](=[C:6]([NH:13][CH3:12])[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1

Participants

3

Reactant 2

HCID 8405IsoquinolineHCID 30849312,2,2-Trifluoro-N-(hydroxymethyl)acetamide

Product 1

HCID 222583221341688-75-2

Procedure

Isoquinoline is reacted with N-(hydroxymethyl)trifluoroacetamide in acid followed by reduction to afford isoquinolin-5-yl-methylamine. Carbamylation using aminotetralin as described above, produces aminotetralin-derived ureas in which L=CH2 (methylene) (Scheme 7).

Sources & evidence

ORD record
ord-635aeae8bf8347e883a2c7fd52c2cb07
Source dataset
uspto-grants-2010_03
Patent number
US07678812B2

Reaction notes

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