Water → HCID 68686425, compound

HRID 2244283Notes

Reaction equation

HRID 2244283 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=3[CH2:14][N:13]3[CH:21]=[CH:22][CH:23]=[C:12]3[CH2:11]2)=[O:9])=[CH:4][C:3]=1[S:24]([NH2:27])(=[O:26])=[O:25].[OH2:28]>N1CCOCC1>[N:10]1([C:2]2[CH:7]=[CH:6][C:5]([C:8]([N:10]3[C:16]4[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=4[CH2:14][N:13]4[CH:21]=[CH:22][CH:23]=[C:12]4[CH2:11]3)=[O:9])=[CH:4][C:3]=2[S:24]([NH2:27])(=[O:26])=[O:25])[CH2:11][CH2:12][O:28][CH2:5][CH2:8]1

Participants

4

Reactant 2

HCID 962WaterHCID 68687807HCID 68687807, compound

Product 1

HCID 68686425HCID 68686425, compound

Reagents, catalysts & solvents 1

HCID 8083MorpholineSolvent

Procedure

A solution of 1 g of 2-chloro-5-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)benzenesulfonamide of Step A in 20 mL of morpholine was heated for 20 hours under reflux. The reaction solution was allowed to cool to room temperature and poured into 50 mL of water with stirring. The precipitate was collected and washed with an additional 50 mL of water and dried to provide the title compound (0.8 g), m.p. 242-245° C. dec

Workup

  1. temperatureunder reflux
  2. customThe precipitate was collected
  3. washwashed with an additional 50 mL of water
  4. customdried

Sources & evidence

ORD record
ord-440c55ba42cd489d8eae066b4a013273
Source dataset
uspto-grants-2010_03
Patent number
US07678787B2

Reaction notes

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