Water → HCID 87540901, compound

HRID 2244285Notes

Reaction equation

HRID 2244285 reaction equation
[N:1]1([C:7]2[CH:12]=[CH:11][C:10]([C:13]([N:15]3[C:21]4[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=4[CH2:19][N:18]4[C:26]([C:29](=[O:34])C(Cl)(Cl)Cl)=[CH:27][CH:28]=[C:17]4[CH2:16]3)=[O:14])=[CH:9][C:8]=2[S:35]([NH2:38])(=[O:37])=[O:36])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[NH2:39][CH2:40][C:41]1[CH:42]=[N:43][CH:44]=[CH:45][CH:46]=1.O>O1CCOCC1>[OH2:4].[NH2:38][S:35]([C:8]1[CH:9]=[C:10]([CH:11]=[CH:12][C:7]=1[N:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1)[C:13]([N:15]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[CH2:19][N:18]2[C:26]([C:29]([NH:39][CH2:40][C:41]3[CH:42]=[N:43][CH:44]=[CH:45][CH:46]=3)=[O:34])=[CH:27][CH:28]=[C:17]2[CH2:16]1)=[O:14])(=[O:37])=[O:36].[NH2:38][S:35]([C:8]1[CH:9]=[C:10]([CH:11]=[CH:12][C:7]=1[N:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1)[C:13]([N:15]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[CH2:19][N:18]2[C:26]([C:29]([NH:39][CH2:40][C:41]3[CH:42]=[N:43][CH:44]=[CH:45][CH:46]=3)=[O:34])=[CH:27][CH:28]=[C:17]2[CH2:16]1)=[O:14])(=[O:37])=[O:36]

Participants

5

Reactant 3

HCID 962WaterHCID 310183-PyridinemethanamineHCID 68689967HCID 68689967, compound

Product 1

HCID 87540901HCID 87540901, compoundYield 63%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution containing 0.83 g (0.0014 mol) of 2-morpholin-4-yl-5-{[3-(trichloroacetyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-yl]carbonyl}benzenesulfonamide of Step C and 0.30 g (0.0028 mol) of 3-aminomethylpyridine in 25 mL of 1,4-dioxane was stirred under reflux overnight. The reaction mixture was allowed to cool to room temperature and poured into 200 mL of water. The beige solid that precipitated was collected and washed with water to provide the title compound (0.35 g), m.p. 159-161° C.

Workup

  1. temperatureunder reflux overnight
  2. customThe beige solid that precipitated was collected
  3. washwashed with water

Sources & evidence

ORD record
ord-ae3e929db7344af19a26aa30845797bf
Source dataset
uspto-grants-2010_03
Patent number
US07678787B2

Reaction notes

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