反应详情

温度

125 °C

A mixture of 2-chloro-5-fluoropyridine-6-carboxylic acid (2.00 g, 11.4 mmol), 41% aq. methylamine solution (8 mL) and 1,4-dioxane (8 mL) was heated at 125° C. under microwave irradiation for 60 min. After cooling, volatile material was distilled off, and the residue was dissolved in water (20 mL) and acidified to pH 3 by addition of 37% aq. hydrochloric acid solution. The precipitate was collected by filtration to produce the title compound (1.85 g, 87%). Light yellow solid, MS (ISP): 185.1 (M−H)−.

1. temperatureAfter cooling
2. distillationvolatile material was distilled off
3. dissolutionthe residue was dissolved in water (20 mL)
4. additionacidified to pH 3 by addition of 37% aq. hydrochloric acid solution
5. filtrationThe precipitate was collected by filtration