Lithium Hydroxide → HCID 68701098, compound

HRID 2244362Notes

Reaction equation

HRID 2244362 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[CH:8][S:9][C:10]=1[NH:11][CH:12]1[CH2:14][CH2:13]1)=[O:5])C.[Li+:15].[OH-]>C1COCC1.CO>[CH:12]1([NH:11][C:10]2[S:9][CH:8]=[N:7][C:6]=2[C:4]([O-:5])=[O:3])[CH2:13][CH2:14]1.[Li+:15]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 64268641HCID 64268641, compound

Product 1

HCID 68701098HCID 68701098, compound

Reagents, catalysts & solvents 1

HCID 21899815MeOH tetrahydrofuranSolvent

Procedure

198 mg of 5-cyclopropylamino-thiazole-4-carboxylic acid ethyl ester (0.93 mmol) were dissolved in a 3:1 mixture of THF/methanol (2 ml) and 1.4 ml of a 1N LiOH-solution were added. The reaction mixture was stirred at RT for 3 days, then concentrated in vacuo and the remaining residue was dried. This gave 191 mg of a yellow solid containing the crude title compound (contaminated with excess of lithium hydroxide) that was used in the following step without further purification. MS (ISP) 182.9 (M−H)−.

Workup

  1. additionwere added
  2. concentrationconcentrated in vacuo
  3. customthe remaining residue was dried
  4. additionThis gave 191 mg of a yellow solid containing the crude title compound (contaminated with excess of lithium hydroxide) that
  5. customwas used in the following step without further purification

Sources & evidence

ORD record
ord-3410eabc3dcc4a9f89efd6d824c807a7
Source dataset
uspto-grants-2010_03
Patent number
US07678818B2

Reaction notes

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