Acetic Anhydride → HCID 58674939, compound

HRID 2244418Notes

Reaction equation

HRID 2244418 reaction equation
[CH3:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[C:4]([N+:9]([O-:11])=[O:10])[N:3]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:1][C:2]1[C:7]([O:8][C:12](=[O:14])[CH3:13])=[CH:6][CH:5]=[C:4]([N+:9]([O-:11])=[O:10])[N:3]=1

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 11430Potassium CarbonateHCID 217660202-Methyl-6-nitro-3-pyridinol

Product 1

HCID 58674939HCID 58674939, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A solution of 2-methyl-6-nitro-pyridin-3-ol (0.77 g, 5.00 mmol) in acetone (50.00 ml) was treated with acetic anhydride (1.00 g, 9.80 mmol) and potassium carbonate (2.07 g, 15.00 mmol). The mixture was stirred for 1 h at room temperature then filtered, washing with acetone. The solvent was removed, yielding acetic acid 2-methyl-6-nitro-pyridin-3-yl ester (0.75 g, 77%) as a white solid, MS (ISP): m/e=196.1 (M+), which was used crude.

Workup

  1. filtrationthen filtered
  2. washwashing with acetone
  3. customThe solvent was removed

Sources & evidence

ORD record
ord-8139debaada54c938bd7142147648bcc
Source dataset
uspto-grants-2010_03
Patent number
US07678815B2

Reaction notes

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