Thiourea → 4-Cyclopropyl-1,3-thiazol-2-amine

HRID 2244466Notes

Reaction equation

HRID 2244466 reaction equation
Br[CH2:2][C:3]([CH:5]1[CH2:7][CH2:6]1)=O.[NH2:8][C:9]([NH2:11])=[S:10]>CO>[CH:5]1([C:3]2[N:8]=[C:9]([NH2:11])[S:10][CH:2]=2)[CH2:7][CH2:6]1

Participants

4

Reactant 2

HCID 2723790ThioureaHCID 109208412-Bromo-1-cyclopropylethan-1-one

Product 1

HCID 6744564-Cyclopropyl-1,3-thiazol-2-amine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 2-Bromo-1-cyclopropyl-ethanone (CAS [69267-75-0], Indian J. Chem. Sect. B, 22(9), 841(1983) (1 g, 6.1 mmol) and thiourea (0.481 g, 6.1 mmol) in 15 ml of methanol was refluxed overnight. The solvent was evaporated off and the title compound was obtained as an off-white solid (1.38 g, 100%).

Workup

  1. customThe solvent was evaporated off

Sources & evidence

ORD record
ord-fe23fdae83a544e5b55373eb1c7ba051
Source dataset
uspto-grants-2010_03
Patent number
US07678815B2

Reaction notes

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