HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiourea → 4-Cyclopropyl-1,3-thiazol-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | 2-Bromo-1-cyclopropylethan-1-one | HCID 10920841 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Cyclopropyl-1,3-thiazol-2-amine | HCID 674456 | — |
Reaction Steps
A solution of 2-Bromo-1-cyclopropyl-ethanone (CAS [69267-75-0], Indian J. Chem. Sect. B, 22(9), 841(1983) (1 g, 6.1 mmol) and thiourea (0.481 g, 6.1 mmol) in 15 ml of methanol was refluxed overnight. The solvent was evaporated off and the title compound was obtained as an off-white solid (1.38 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07678815B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-fe23fdae83a544e5b55373eb1c7ba051 |
| Source note | uspto-grants-2010_03 |