[4-Chloro-2-(2-hydroxy-benzyl)-phenoxy]-acetic acid methyl ester → 2-[2-(5-Chloro-2-methoxycarbonylmethoxy-benzyl)-phenoxy]-propionic acid

HRID 2244474Notes

Reaction equation

HRID 2244474 reaction equation
[CH2:1]([O:8][C:9]([CH2:11][O:12][C:13]1[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][C:14]=1[CH2:15][C:16]1[CH:27]=[C:26](Cl)[CH:25]=[CH:24][C:17]=1[O:18][CH:19]([CH3:23])[C:20]([OH:22])=[O:21])=[O:10])C1C=CC=CC=1.COC(=O)COC1C=CC(Cl)=CC=1CC1C=CC=CC=1O>>[Cl:33][C:30]1[CH:31]=[CH:32][C:13]([O:12][CH2:11][C:9]([O:8][CH3:1])=[O:10])=[C:14]([CH:29]=1)[CH2:15][C:16]1[CH:27]=[CH:26][CH:25]=[CH:24][C:17]=1[O:18][CH:19]([CH3:23])[C:20]([OH:22])=[O:21]

Participants

3

Reactant 2

HCID 68451833[4-Chloro-2-(2-hydroxy-benzyl)-phenoxy]-acetic acid methyl esterHCID 684525502-[2-(2-Benzyloxycarbonylmethoxy-5-chloro-benzyl)-4-chloro-phenoxy]-propionic acid

Product 1

HCID 684527892-[2-(5-Chloro-2-methoxycarbonylmethoxy-benzyl)-phenoxy]-propionic acid

Procedure

The titled compound is prepared analogously to 2-[2-(2-benzyloxycarbonylmethoxy-5-chloro-benzyl)-4-chloro-phenoxy]-propionic acid by replacing [4-chloro-2-(5-chloro-2-hydroxy-benzyl)-phenoxy]-acetic acid benzyl ester with [4-chloro-2-(2-hydroxy-benzyl)-phenoxy]-acetic acid methyl ester.

Sources & evidence

ORD record
ord-584e1bfaa2ba487fb58f715989400f8e
Source dataset
uspto-grants-2010_03
Patent number
US07678826B2

Reaction notes

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