Hydrochloric Acid → 1-Methyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole

HRID 2244574Notes

Reaction equation

HRID 2244574 reaction equation
[CH3:1][N:2]1[C:6]2[CH2:7][N:8](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH2:9][C:5]=2[CH:4]=[N:3]1.Cl>>[CH3:1][N:2]1[C:6]2[CH2:7][NH:8][CH2:9][C:5]=2[CH:4]=[N:3]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 67128179HCID 67128179, compound

Product 1

HCID 108780601-Methyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole

Procedure

1-Methyl-5-trityl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole (670 mg) obtained in Step A above was treated with 4N hydrochloric acid (4 mL). After 1.5 h, the reaction mixture was concentrated. The residue was purified on a Biotage Horizon® system (silica, gradient 10-19% methanol containing 10% concentrated ammonium hydroxide in dichloromethane) to yield 1-methyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole. LC-MS 124.1 (M+1).

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customThe residue was purified on a Biotage Horizon® system (silica, gradient 10-19% methanol containing 10% concentrated ammonium hydroxide in dichloromethane)

Sources & evidence

ORD record
ord-7ae6ec1bd35a4db0907eb1e6cd8a96be
Source dataset
uspto-grants-2010_03
Patent number
US07678905B2

Reaction notes

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