Sodium Bicarbonate → HCID 59215162, compound

HRID 2244592Notes

Reaction equation

HRID 2244592 reaction equation
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][C:6]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=3)=[N:7][C:8]=2[Cl:12])[N:3]=1.C(=O)(O)[O-:22].[Na+]>>[Cl:12][C:8]1[N:7]=[C:6]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)[CH:5]=[C:4]2[C:9]=1[CH:10]=[CH:11][C:2](=[O:22])[NH:3]2

Participants

3

Reactant 2

HCID 516892Sodium BicarbonateHCID 59215152HCID 59215152, compound

Product 1

HCID 59215162HCID 59215162, compoundYield 32%

Procedure

2,5-Dichloro-7-(4-methoxyphenyl)-[1,6]naphthyridine (Example 26) (700 mg, 2.29 mmol) was stirred in saturated sodium bicarbonate solution (100 mL) for 20 minutes. A white solid precipitated and was isolated by vacuum filtration to afford 5-chloro-7-(4-methoxy-phenyl)-1H-[1,6]naphthyridin-2-one (209 mg, 32%).

Workup

  1. customA white solid precipitated
  2. customwas isolated by vacuum filtration

Sources & evidence

ORD record
ord-2ae663807c0645e9b5750cb3b2075bc3
Source dataset
uspto-grants-2010_03
Patent number
US07678911B2

Reaction notes

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