Sodium Bicarbonate → HCID 11194669, compound

HRID 2244594Notes

Reaction equation

HRID 2244594 reaction equation
C(=O)([O-])O.[Na+].O.Cl.[C:8]([C:10]1[S:11][C:12]2[CH2:13][N:14]([CH3:19])[CH2:15][CH2:16][C:17]=2[N:18]=1)#[N:9]>O>[C:8]([C:10]1[S:11][C:12]2[CH2:13][N:14]([CH3:19])[CH2:15][CH2:16][C:17]=2[N:18]=1)#[N:9]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 23135439HCID 23135439, compound

Product 1

HCID 11194669HCID 11194669, compoundYield 100.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of sodium hydrogencarbonate (272.33 mg) in water (5 mL) was added to 2-cyano-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine hydrochloride monohydrate (500.30 mg) at room temperature, and after all ingredients were completely dissolved, the resultant solution was extracted with toluene three times (10 mL×3). The toluene layers were combined, and the combined toluene layer was dried over sodium sulfate anhydrate (2.00 g). After any insoluble material was filtered off, the filtrate was concentrated at 40° C. under reduced pressure, to thereby give 384.28 mg of the title compound.

Workup

  1. dissolutionafter all ingredients were completely dissolved
  2. extractionthe resultant solution was extracted with toluene three times (10 mL×3)
  3. dry with materialthe combined toluene layer was dried over sodium sulfate anhydrate (2.00 g)
  4. filtrationAfter any insoluble material was filtered off
  5. concentrationthe filtrate was concentrated at 40° C. under reduced pressure

Sources & evidence

ORD record
ord-11080a83e16c4f539b5300d21e63c370
Source dataset
uspto-grants-2010_03
Patent number
US07678910B2

Reaction notes

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