Hydrochloric Acid → 5-Methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxylic acid--hydrogen chloride (1/1)

HRID 2244599Notes

Reaction equation

HRID 2244599 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][C:5]2[N:8]=[C:9]([C:11]([O-:13])=[O:12])[S:10][C:4]=2[CH2:3]1.[Li+].[ClH:15]>C(O)C>[ClH:15].[CH3:1][N:2]1[CH2:7][CH2:6][C:5]2[N:8]=[C:9]([C:11]([OH:13])=[O:12])[S:10][C:4]=2[CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23704331Lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate

Product 1

HCID 111490315-Methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxylic acid--hydrogen chloride (1/1)

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate (3.00 g) was added 1N HCl in ethanol (36 mL), and the mixture was stirred at room temperature for 1 hour. The precipitated crystals were collected by filtration, and were washed with ethanol (9 mL). The wet crystal was dried at room temperature under reduced pressure, to thereby give 2.76 g of the title compound.

Workup

  1. filtrationThe precipitated crystals were collected by filtration
  2. washwere washed with ethanol (9 mL)
  3. customThe wet crystal was dried at room temperature under reduced pressure

Sources & evidence

ORD record
ord-d11214c0f89541afbcd96f0509d6e919
Source dataset
uspto-grants-2010_03
Patent number
US07678910B2

Reaction notes

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