HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1R,3S,4S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-hydroxy-cyclopentanecarboxylic acid methyl ester → 5-chloro-thiophene-2-carboxylic acid {(1S,2S,4R)-2-hydroxy-4-[2-methyl-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-cyclopentyl}-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1R,3S,4S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-hydroxy-cyclopentanecarboxylic acid methyl ester | HCID 58826431 | — |
| Reactant | 1-(4-Amino-3-methylphenyl)pyridin-2(1H)-one | HCID 66882353 | — |
| Product | 5-chloro-thiophene-2-carboxylic acid {(1S,2S,4R)-2-hydroxy-4-[2-methyl-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-cyclopentyl}-amide | HCID 16066159 | — |
Reaction Steps
In analogy to example 1C, (1R,3S,4S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-hydroxy-cyclopentanecarboxylic acid methyl ester (example 1B) was reacted with 1-(4-amino-3-methyl-phenyl)-1H-pyridin-2-one to give 5-chloro-thiophene-2-carboxylic acid {(1S,2S,4R)-2-hydroxy-4-[2-methyl-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-cyclopentyl}-amide. Off-white solid. MS: 472.4 ([M+H]+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07678917B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-3915b8de317f4de6bc8d068996aea13e |
| Source note | uspto-grants-2010_03 |