1-(4-Aminophenyl)-1H-pyridin-2-one → 5-chloro-thiophene-2-carboxylic acid {(1S,2S,4R)-2-hydroxy-4-[4-(2-oxo-2H-pyridin-1-yl)-phenyl-carbamoyl]-cyclopentyl}-amide

Participants

Reaction Steps

In analogy to example 1C, (1R,3S,4S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-hydroxy-cyclopentanecarboxylic acid methyl ester (example 1B) was reacted with 1-(4-amino-phenyl)-1H-pyridin-2-one (CAS 13143-47-0) to give 5-chloro-thiophene-2-carboxylic acid {(1S,2S,4R)-2-hydroxy-4-[4-(2-oxo-2H-pyridin-1-yl)-phenyl-carbamoyl]-cyclopentyl}-amide. Orange solid. MS: 458.3 ([M+H]+).

Provenance & Evidence