Methyl Ethyl Ketone → 4-Hydroxy-2,3-dimethyl-6-tetradecanoylphenyl allyl ether

HRID 224468ノート

反応式

HRID 224468 の反応式
[CH2:1](Br)[CH:2]=[CH2:3].[CH3:5][C:6]1[C:12]([CH3:13])=[C:11]([OH:14])[CH:10]=[C:9]([C:15](=[O:29])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[C:7]=1[OH:8].C(=O)([O-])[O-].[K+].[K+].C(C(C)=O)C>O>[CH2:1]([O:8][C:7]1[C:9]([C:15](=[O:29])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=[CH:10][C:11]([OH:14])=[C:12]([CH3:13])[C:6]=1[CH3:5])[CH:2]=[CH2:3]

参加物

6

反応物 4

HCID 6569Methyl Ethyl KetoneHCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 205104672,3-Dimethyl-6-myristoyl-hydroquinone

生成物 1

HCID 233332484-Hydroxy-2,3-dimethyl-6-tetradecanoylphenyl allyl ether

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
30 °C

実験手順

43 g of allyl bromide were dropwise added with gentle boiling within 2 h to a mixture of 105 g of the ketone of step 1, 63 g of potassium carbonate and 1200 ml of methyl ethyl ketone. After 9 h of boiling the mixture was cooled to 30° C. and 200 ml of water were added. The aqueous layer was separated. Then the organic layer was shaken once with a 25% by weight sodium chloride solution and filtered off, whereupon the solvent was distilled. The residue was stirred into 1 l of methanol and filtered with suction.

後処理

  1. customThe aqueous layer was separated
  2. filtrationfiltered off, whereupon the solvent
  3. distillationwas distilled
  4. stirringThe residue was stirred into 1 l of methanol
  5. filtrationfiltered with suction

出典と根拠

ORDレコード
ord-2ef57827e63a452693498e69e8516f33
出典データセット
uspto-grants-1980_11
特許番号
US04232107

反応ノート

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