反应详情

温度

30 °C

43 g of allyl bromide were dropwise added with gentle boiling within 2 h to a mixture of 105 g of the ketone of step 1, 63 g of potassium carbonate and 1200 ml of methyl ethyl ketone. After 9 h of boiling the mixture was cooled to 30° C. and 200 ml of water were added. The aqueous layer was separated. Then the organic layer was shaken once with a 25% by weight sodium chloride solution and filtered off, whereupon the solvent was distilled. The residue was stirred into 1 l of methanol and filtered with suction.

1. customThe aqueous layer was separated
2. filtrationfiltered off, whereupon the solvent
3. distillationwas distilled
4. stirringThe residue was stirred into 1 l of methanol
5. filtrationfiltered with suction