反应详情

115.0 g (0.88 mol) of 2,3-difluorophenol are refluxed for 3 h together with 118.2 ml (17.7 mol) of propargyl bromide (80% soln. in toluene) and 146.6 g (138.2 mol) of potassium carbonate in 1.6 l of ethyl methyl ketone. The batch is filtered, and the filter residue is washed with MTBE. The filtrate is concentrated to dryness, and the residue is purified by column chromatography (SiO2, n-heptane:MTBE=3:1).

1. filtrationThe batch is filtered
2. washthe filter residue is washed with MTBE
3. concentrationThe filtrate is concentrated to dryness
4. customthe residue is purified by column chromatography (SiO2, n-heptane:MTBE=3:1)