反应详情

50.0 g (0.24 mol) of 5-bromo-2,3-difluorophenol are refluxed for 3 h together with 32.0 ml (0.29 mol) of propargyl bromide (80% soln. in toluene) and 39.7 g (0.29 mol) of potassium carbonate in 860 ml of ethyl methyl ketone. The batch is filtered, and the filter residue is washed with MTBE. The filtrate is concentrated to dryness, and the residue is purified by column chromatography (SiO2, n-heptane:MTBE=3:1).

1. filtrationThe batch is filtered
2. washthe filter residue is washed with MTBE
3. concentrationThe filtrate is concentrated to dryness
4. customthe residue is purified by column chromatography (SiO2, n-heptane:MTBE=3:1)