HCID 59212643, compound → HCID 59212620, compound

HRID 2244890Notes

Reaction equation

HRID 2244890 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH:7]([N:11]1[CH2:16][CH2:15][N:14]([C:17]3([CH3:30])[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]3)[CH2:13][C@@H:12]1[CH3:31])[CH2:6][CH2:5]2>Cl.O1CCOCC1>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH:7]([N:11]1[CH2:16][CH2:15][N:14]([C:17]3([CH3:30])[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)[CH2:13][C@@H:12]1[CH3:31])[CH2:6][CH2:5]2

Participants

4

Reactant 1

HCID 59212643HCID 59212643, compound

Product 1

HCID 59212620HCID 59212620, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

The intermediate obtained from step E (0.23 g) was dissolved in a solution of 4 N HCl in dioxane (3 mL). After being stirred at room temperature for 2 h, the solution was concentrated to provide the title compound as a trihydrochloride salt (0.23 g). MS calculated for C20H30BrN3: (M+H)+ 392; found 392.2, 394.2.

Workup

  1. concentrationthe solution was concentrated

Sources & evidence

ORD record
ord-08881c64714a498dbca6e1673b97c4f2
Source dataset
uspto-grants-2010_03
Patent number
US07678798B2

Reaction notes

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