Sodium Hydroxide → HCID 68692400, compound

HRID 2244983Notes

Reaction equation

HRID 2244983 reaction equation
[CH3:1][N:2]1[CH2:6][CH2:5][N:4]=[C:3]1[C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14](=[O:38])[C:15]([CH:35]=[C:36]=[O:37])(OCC2C=CC=CC=2)[NH:16][C:17]([NH:19][C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=2)=[O:18])=[CH:9][CH:8]=1.[OH-:39].[Na+]>CO>[CH3:1][N:2]1[CH2:6][CH2:5][N:4]=[C:3]1[C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14](=[O:38])[CH:15]([CH2:35][C:36]([OH:37])=[O:39])[NH:16][C:17]([NH:19][C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=2)=[O:18])=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86606528HCID 86606528, compound

Product 1

HCID 68692400HCID 68692400, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of (2S) N-[4-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)phenyl]-2-benzyloxycarbonylmethyl-2-(4-chlorophenylaminocarbonylamino)-acetamide (from EXAMPLE 59, 60 mg, 0.11 mmol) in MeOH (3 mL) at room temperature, 1N aq. NaOH (0.50 mL) was added. After being stirred at room temperature overnight, the mixture was concentrated in vacuo. The residue (after being neutralized to acidic with TFA) was purified by HPLC to give the titled compound as a powder (26 mg). MS

Workup

  1. concentrationthe mixture was concentrated in vacuo
  2. customThe residue (after being neutralized to acidic with TFA) was purified by HPLC

Sources & evidence

ORD record
ord-c9d3cfc49290461ea5b8413cbd1598ad
Source dataset
uspto-grants-2010_03
Patent number
US07678913B2

Reaction notes

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