Sodium Hydroxide → HCID 68692400, compound

Participants

Reaction Steps

To a solution of (2S) N-[4-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)phenyl]-2-benzyloxycarbonylmethyl-2-(4-chlorophenylaminocarbonylamino)-acetamide (from EXAMPLE 59, 60 mg, 0.11 mmol) in MeOH (3 mL) at room temperature, 1N aq. NaOH (0.50 mL) was added. After being stirred at room temperature overnight, the mixture was concentrated in vacuo. The residue (after being neutralized to acidic with TFA) was purified by HPLC to give the titled compound as a powder (26 mg). MS

Provenance & Evidence