1,2-Dichloroethane → N-[4-(N-methyl-N-pyridin-4-yl-amino)phenyl]-2-(2-methylphenyl)-2-(4-chlorophenylaminocarbonylamino)-acetamide

HRID 2244996Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2244996
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([NH:12][C:13]([NH:15][C:16]1[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=1)=[O:14])[C:9]([OH:11])=O.[CH3:23][N:24]([C:31]1[CH:36]=[CH:35][C:34]([NH2:37])=[CH:33][CH:32]=1)[C:25]1[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=1.C(Cl)CCl>CN(C=O)C>[CH3:23][N:24]([C:31]1[CH:36]=[CH:35][C:34]([NH:37][C:9](=[O:11])[CH:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[CH3:1])[NH:12][C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)=[O:14])=[CH:33][CH:32]=1)[C:25]1[CH:26]=[CH:27][N:28]=[CH:29][CH:30]=1

Komponenten

5

Edukt 3

HCID 111,2-DichloroethaneHCID 230230924-(N-methyl-N-pyridin-4-yl-amino)phenylamineHCID 686898412-(2-Methylphenyl)-2-(4-chlorophenylaminocarbonylamino)-acetic acid

Produkt 1

HCID 11598530N-[4-(N-methyl-N-pyridin-4-yl-amino)phenyl]-2-(2-methylphenyl)-2-(4-chlorophenylaminocarbonylamino)-acetamideAusbeute 32,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a solution of 2-(2-methylphenyl)-2-(4-chlorophenylaminocarbonylamino)-acetic acid (53 mg, 0.17 mmol) and 4-(N-methyl-N-pyridin-4-yl-amino)phenylamine (47 mg, 0.24 mmol) in DMF (3 mL), EDC (73 mg, 0.38 mmol) was added. The reaction mixture was stirred at room temperature overnight. It was then concentrated in vacuo. The residue was purified by HPLC to give the titled compound as a white powder (28 mg). MS 500.2 and 502.2 (M+H, Cl pattern).

Aufarbeitung

  1. concentrationIt was then concentrated in vacuo
  2. customThe residue was purified by HPLC

Quellen und Nachweise

ORD-Eintrag
ord-e86b8293dcfc41c289f76ac825d21332
Quelldatensatz
uspto-grants-2010_03
Patentnummer
US07678913B2

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