反应详情

The reaction of 1,2-dimethyl-5-nitroimidazole with oxalic acid ethyl ester chloride in the course of 22 hours in the presence of triethylamine and of substantial amounts of ether gives 1-carbethoxy-2-(1-methyl-5-nitro-imidazol-2-yl)-vinyl ethyl oxalate in 54 percent yield; the latter compound, on treatment with ethanol, gives 1-methyl-5-nitro-imidazol-2-yl-pyruvic acid ethyl ester in 43 percent yield (J. Heterocycl., loc. cit., 904 and 905). ##STR4##