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HRID2245046

反应详情

EQUATION

反应方程式

HRID 2245046 的结构方程式

REACTANTS

反应物

2
结构：Nc1ccc(F)cc1
HCID9731

4-Fluoroaniline

C6H6FN

结构：CSc1nc(-c2cc(C(=O)O)ccc2C)c2ccc(=O)n(-c3c(F)cccc3F)c2n1
HCID57530530

未命名化合物

PRODUCTS

生成物

1
结构：CSc1nc(-c2cc(C(=O)Nc3ccc(F)cc3)ccc2C)c2ccc(=O)n(-c3c(F)cccc3F)c2n1
HCID59212682

未命名化合物

收率 34%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCCl
溶剂HCID11

1,2-Dichloroethane

C2H4Cl2

PROCEDURE

实验过程

The title compound was prepared from 3-[8-(2,6-difluorophenyl)-2-(methylthio)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl]-4-methylbenzoic acid and 4-fluoroaniline by following the General Procedure for EDC couplings as disclosed in the general experimental section above. Crude reaction mixture was purified via flash chromatography (EtOAc:Hexanes, 2:1) to afford the title compound (0.125 g, 34%).

WORKUP

后处理

  1. customCrude reaction mixture
  2. customwas purified via flash chromatography (EtOAc:Hexanes, 2:1)