Imidazole → HCID 12786182, compound

Participants

Reaction Steps

To a solution of 30.0 g. of 4-hydroxy-5-methylene-1-octyne and 31.02 g. of imidazole in 80 ml. of dimethylformamide at 0° C., is added 40.9 g. of triethylchlorosilane. The mixture is stirred at room temperature for 30 minutes, poured into cold water and extracted with petroleum ether. The petroleum ether is removed and the residue is distilled. The product is recovered in the fraction boiling at 103°-106° C. (1.5 mm.).

Provenance & Evidence