Imidazole → HCID 12786182, compound

HRID 224511Notes

Reaction equation

HRID 224511 reaction equation
[OH:1][CH:2]([C:6](=[CH2:10])[CH2:7][CH2:8][CH3:9])[CH2:3][C:4]#[CH:5].N1C=CN=C1.CN(C)C=O.[CH2:21]([Si:23]([CH2:27][CH3:28])([CH2:25][CH3:26])Cl)[CH3:22]>O>[CH2:10]=[C:6]([CH2:7][CH2:8][CH3:9])[CH:2]([O:1][Si:23]([CH2:27][CH3:28])([CH2:25][CH3:26])[CH2:21][CH3:22])[CH2:3][C:4]#[CH:5]

Participants

6

Reactant 4

HCID 795ImidazoleHCID 6228DimethylformamideHCID 13819ChlorotriethylsilaneHCID 20565008HCID 20565008, compound

Product 1

HCID 12786182HCID 12786182, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 30.0 g. of 4-hydroxy-5-methylene-1-octyne and 31.02 g. of imidazole in 80 ml. of dimethylformamide at 0° C., is added 40.9 g. of triethylchlorosilane. The mixture is stirred at room temperature for 30 minutes, poured into cold water and extracted with petroleum ether. The petroleum ether is removed and the residue is distilled. The product is recovered in the fraction boiling at 103°-106° C. (1.5 mm.).

Workup

  1. extractionextracted with petroleum ether
  2. customThe petroleum ether is removed
  3. distillationthe residue is distilled
  4. customThe product is recovered in the fraction boiling at 103°-106° C. (1.5 mm.)

Sources & evidence

ORD record
ord-86a78ef2cf5f4bd7aa89a44bf319bc0f
Source dataset
uspto-grants-1980_11
Patent number
US04232166

Reaction notes

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