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HRID2245214

反应详情

EQUATION

反应方程式

HRID 2245214 的结构方程式

REACTANTS

反应物

3
结构：Cl
HCID313

Hydrochloric Acid

ClH

2 次

结构：CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)C(N)=O
HCID11141514

未命名化合物

2 次

结构：C(=NC1CCCCC1)=NC1CCCCC1.On1nnc2ccccc21
HCID21712060

未命名化合物

PRODUCTS

生成物

2
结构：CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)O
HCID85083

1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)-

C10H17NO4

结构：CC(C)[C@H](NC(=O)OC(C)(C)C)C(N)=O
HCID11241393

Boc-L-valine amide

C10H20N2O3

PROCEDURE

实验过程

In such a synthesis, the lysine side chain is protected by a MSOC protective group introduced onto Boc-Lys-OH so as to form Boc-Lys(MSOC)-OH. The diprotected N(α),N(ε) lysine is coupled with Boc-Pro-Val-NH2, HCl by the conventional DCC/HOBt method. The Boc-Pro-Val-NH2, HCl reactant is in turn obtained in two steps from Boc-Pro-OH and Boc-Val-NH2. The overall yield is 33% calculated based on Boc-Lys(MSOC)-OH. The global synthesis scheme is illustrated in the scheme (I) hereunder: