HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Ac-D-Lys(Z)-D-Pro-OBzl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | H-D-Lys(Z)-D-Pro-OBzl | HCID 131727989 | — |
| Solvent | Water | HCID 962 | — |
| Product | Ac-D-Lys(Z)-D-Pro-OBzl | HCID 131727988 | — |
Reaction Steps
The previously obtained chloromethylene solution of HCl, H-D-Lys(Z)-D-Pro-OBzl is cooled down to 5° C., added with 135 ml of water, followed by 32.3 ml of acetic anhydride (1.5 eq). At Qsp pH 10 is then added within 30 minutes to 1 hour an aqueous 5N NaOH (90 to 130 ml are required).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07683026B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-1ed88d2884a14607875fe1095dbff306 |
| Source note | uspto-grants-2010_03 |